Swine Vaccines
Swine Vaccines
BIO-MYCIN® 200
Boehringer Ingelheim
Caution:
When administered to cattle muscle discoloration may necessitate trimming of the injection site(s) and surrounding tissues during the dressing procedure.
 | Warning: Discontinue treatment at least 28 days prior to slaughter of cattle and swine. Milk taken from animals during treatment and for 96 hours after the last treatment must not be used for food. Rapid intravenous administration may result in animal collapse. Oxytetracycline should be administered intravenously slowly over a period of at least 5 minutes. |
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Precautions:
Exceeding the highest recommended dosage level of drug per pound of body weight per day administering more than the recommended number of treatments and/or exceeding 10 mL intramuscularly or subcutaneously per injection site in adult beef cattle and dairy cattle and 5 mL intramuscularly per injection site in adult swine may result in antibiotic residues beyond the withdrawal period.
Consult with your veterinarian prior to administering this product in order to determine the proper treatment required in the event of an adverse reaction. At the first sign of any adverse reaction discontinue use of product and seek the advice of your veterinarian. Some of the reactions may be attributed either to anaphylaxis (an allergic reaction) or to cardiovascular collapse of unknown cause.
Shortly after injection treated animals may have transient hemoglobinuria resulting in darkened urine.
As with all antibiotic preparations use of this drug may result in overgrowth of nonsusceptible organisms including fungi. A lack of response by the treated animal or the development of new signs may suggest that an overgrowth of nonsusceptible organisms has occurred. If any of these conditions occur consult your veterinarian.
Since bacteriostatic drugs may interfere with the bactericidal action of penicillin it is advisable to avoid giving Bio-Mycin 200 in conjunction with penicillin.
Adverse Reactions:
Reports of adverse reactions associated with oxytetracycline administration include injection site swelling restlessness ataxia trembling swelling of eyelids ears muzzle anus and vulva (or scrotum and sheath in males) respiratory abnormalities (labored breathing) frothing at the mouth collapse and possibly death. Some of these reactions may be attributed either to anaphylaxis (an allergic reaction) or to cardiovascular collapse of unknown cause.
Storage:
Store at controlled room temperature 15°-25° C (59°-77° F). Keep from freezing.
Care of Sick Animals:
The use of antibiotics in the management of diseases is based on an accurate diagnosis and an adequate course of treatment. When properly used in the treatment of diseases caused by oxytetracycline susceptible organisms most animals that have been treated with oxytetracycline injection show a noticeable improvement within 24 to 48 hours. It is recommended that the diagnosis and treatment of animal diseases be carried out by a veterinarian. Since many diseases look alike but require different types of treatment the use of professional veterinary and laboratory services can reduce treatment time costs and needless losses. Good housing sanitation and nutrition are important in the maintenance of healthy animals and are essential in the treatment of diseased animals.
Indications:
Bio-Mycin 200 is intended for use in the treatment of the following diseases in beef cattle dairy cattle and swine when due to oxytetracycline-susceptible organisms:
Cattle: In cattle Bio-Mycin 200 is indicated in the treatment of pneumonia and shipping fever complex associated with Pasteurella spp. and Haemophilus spp.; infectious bovine keratoconjunctivitis (pinkeye) caused by Moraxella bovis; foot-rot and diphtheria caused by Fusobacterium necrophorum; bacterial enteritis (scours) caused by Escherichia coli; wooden tongue caused by Actinobacillus lignieresii; leptospirosis caused by Leptospira pomona; and wound infections and acute metritis caused by strains of staphylococci and streptococci organisms sensitive to oxytetracycline.
Swine: In swine Bio-Mycin 200 is indicated in the treatment of bacterial enteritis (scours colibacillosis) caused by Escherichia coli; pneumonia caused by Pasteurella multocida; and leptospirosis caused by Leptospira pomona.
In sows Bio-Mycin 200 is indicated as an aid in the control of infectious enteritis (baby pig scours colibacillosis) in suckling pigs caused by Escherichia coli.
Dosage:
Cattle: Bio-Mycin 200 is to be administered by intramuscular subcutaneous or intravenous injection to beef cattle and dairy cattle.
A single dosage of 9 milligrams of Bio-Mycin 200 per pound of body weight administered intramuscularly or subcutaneously is recommended in the treatment of the following conditions: 1) bacterial pneumonia caused by Pasteurella spp. (shipping fever) in calves and yearlings where retreatment is impractical due to husbandry conditions such as cattle on range or where their repeated restraint is inadvisable; 2) infectious bovine keratoconjunctivitis (pinkeye) caused by Moraxella bovis.
Cattle Dosage Guide
At the first signs of pneumonia or pinkeye* administer a single dose of Bio-Mycin® 200 by deep intramuscular injection or subcutaneous injection according to the following weight categories**
| Animal weight (lb) | Number of mL or cc | Animal weight (lb) | Number of mL or cc | Animal weight (lb) | Number of mL or cc |
| 100 | 4.5 | 500 | 22.5 | 900 | 40.5 |
| 200 | 9.0 | 600 | 27.0 | 1000 | 45.0 |
| 300 | 13.5 | 700 | 31.5 | 1100 | 49.5 |
| 400 | 18.0 | 800 | 36.0 | 1200 | 54.0 |
**Do not administer more than 10 mL at any one injection site (1 to 2 mL per site in small calves).
 | Discontinue treatment at least 28 days prior to slaughter of cattle. Milk taken from animals during treatment and for 96 hours after the last treatment must not be used for food. |  |
Bio-Mycin 200 can also be administered by intravenous subcutaneous or intramuscular injection at a level of 3 to 5 milligrams of oxytetracycline per pound of body weight per day. In the treatment of severe foot-rot and advanced cases of other indicated diseases a dosage level of 5 milligrams per pound of body weight per day is recommended. Treatment should be continued 24 to 48 hours following remission of disease signs; however not to exceed a total of four consecutive days. Consult your veterinarian if improvement is not noted within 24 to 48 hours of the beginning of treatment.
Swine:
In swine a single dosage of 9 milligrams of Bio-Mycin 200 per pound of body weight administered intramuscularly is recommended in the treatment of bacterial pneumonia caused by Pasteurella multocida in swine where retreatment is impractical due to husbandry conditions or where repeated restraint is inadvisable.
(oxytetracycline) Injection
Antibiotic
ANADA 200-008 Approved by FDA
Each mL contains 200 mg of oxytetracycline base as oxytetracycline amphoteric.
For the treatment of disease in beef cattle dairy cattle and swine.
Read entire insert carefully before using this product.
Bio-Mycin 200 does not require refrigeration; however it is recommended that it be stored at controlled room temperature 15°-25° C (59°-77° F). The antibiotic activity of oxytetracycline is not appreciably diminished in the presence of body fluids serum or exudates.
Swine Dosage Guide
At the first signs of pneumonia* administer a single dose of Bio-Mycin® 200 by deep intramuscular injection according to the following weight categories**
| Animal weight (lb) | Number of mL or cc | Animal weight (lb) | Number of mL or cc | Animal weight (lb) | Number of mL or cc |
| 10 | 0.5 | 125 | 5.6 | 250 | 11.3 |
| 25 | 1.1 | 150 | 6.8 | 275 | 12.4 |
| 50 | 2.3 | 175 | 7.9 | 300 | 13.5 |
| 75 | 3.4 | 200 | 9.0 | 325 | 14.6 |
| 100 | 4.5 | 225 | 10.1 |
**Do not administer more than 5 mL at any one injection site.
| Discontinue treatment 28 days prior to slaughter of swine. | |
Bio-Mycin 200 can also be administered by intramuscular injection at a level of 3 to 5 milligrams of oxytetracycline per pound of body weight per day.
Treatment should be continued 24 to 48 hours following remission of disease signs; however not to exceed a total of four consecutive days. Consult your veterinarian if improvement is not noted within 24 to 48 hours of the beginning of treatment.
For sows administer once intramuscularly 3 milligrams of oxytetracycline per pound of body weight approximately 8 hours before farrowing or immediately after completion of farrowing.
For swine weighing 25 lb of body weight and under Bio-Mycin 200 should be administered undiluted for treatment at 9 mg/lb but should be administered diluted for treatment at 3 or 5 mg/lb.
| Body Weight | 9 MG/LB DOSAGE Volume of UNDILUTED Bio-Mycin 200 | 3 or 5 MG/LB DOSAGE Volume of DILUTED Bio-Mycin 200 | ||
| 9 mg/lb | 3 mg/lb | Dilution* | 5 mg/lb | |
| 5 lb | 0.2 mL | 0.6 mL | 1:7 | 1.0 mL |
| 10 lb | 0.5 mL | 0.9 mL | 1:5 | 1.5 mL |
| 20 lb | 1.1 mL | 1.5 mL | 1:3 | 2.5 mL |
Directions for Use:
Bio-Mycin 200 is intended for use in the treatment of disease due to oxytetracycline susceptible organisms in beef cattle dairy cattle and swine. A thoroughly cleaned sterile needle and syringe should be used for each injection (needles and syringes may be sterilized by boiling in water for 15 minutes). In cold weather Bio-Mycin 200 should be warmed to room temperature before administration to animals. Before withdrawing the solution from the bottle disinfect the rubber cap on the bottle with a suitable disinfectant such as 70% alcohol. The injection site should be similarly cleaned with the disinfectant. Needles of 16 to 18 gauge and 1 to 1 1/2 inches long are adequate for intramuscular injections. Needles 2 to 3 inches are recommended for intravenous use.
Intramuscular Administration:
Intramuscular injections should be made by directing the needle of suitable gauge and length into the fleshy part of a thick muscle such as in the rump hip or thigh regions; avoid blood vessels and major nerves. Before injecting the solution pull back gently on the plunger. If blood appears in the syringe a blood vessel has been entered; withdraw the needle and select a different site.
No more than 10 mL should be injected intramuscularly at any one site in adult beef cattle and dairy cattle and not more than 5 mL per site in adult swine; rotate injection sites for each succeeding treatment. The volume administered per injection site should be reduced according to age and body size so that 1 to 2 mL per site is injected in small calves.
Subcutaneous Administration: Subcutaneous injections in beef cattle and dairy cattle should be made by directing the needle of suitable gauge and length through the loose folds of the neck skin in front of the shoulder. Care should be taken to ensure that the tip of the needle has penetrated the skin but is not lodged in muscle. Before injecting the solution pull back gently on the plunger. If blood appears in the syringe a blood vessel has been entered; withdraw the needle and select a different site. The solution should be injected slowly into the area between the skin and muscles.
No more than 10 mL should be injected subcutaneously at any one site in adult beef cattle and dairy cattle; rotate injection sites for each succeeding treatment. The volume administered per injection site should be reduced according to age and body size so that 1 to 2 mL per site is injected in small calves.
Intravenous Administration:
Bio-Mycin 200 (oxytetracycline injection) may be administered intravenously to beef cattle and dairy cattle. As with all highly concentrated materials Bio-Mycin 200 should be administered slowly by the intravenous route.
Preparation of the Animal for Injection:
- Approximate location of vein. The jugular vein runs in the jugular groove on each side of the neck from the angle of the jaw to just above the brisket and slightly above and to the side of the windpipe. (See Fig. I).
- Restraint. A stanchion or chute is ideal for restraining the animal. With a halter rope or cattle leader (nose tongs) pull the animal's head around the side of the stanchion cattle chute or post in such a manner to form a bow in the neck (See Fig. II) then snub the head securely to prevent movement. By forming the bow in the neck the outside curvature of the bow tends to expose the jugular vein and make it easily accessible. Caution: Avoid restraining the animal with a tight rope or halter around the throat or upper neck which might impede blood flow. Animals that are down present no problem as far as restraint is concerned.
- Clip hair in area where injection is to be made (over the vein in the upper third of the neck). Clean and disinfect the skin with alcohol or other suitable antiseptic.
Entering the Vein and Making the Injection:
- Raise the vein. This is accomplished by tying the choke rope tightly around the neck close to the shoulder. The rope should be tied in such a way that it will not come loose and so that it can be untied quickly by pulling the loose end (See Fig. II). In thick-necked animals a block of wood placed in the jugular groove between the rope and the hide will help considerably in applying the desired pressure at the right point. The vein is a soft flexible tube through which the blood flows back to the heart. Under ordinary conditions it cannot be seen or felt with the fingers. When the flow of blood is blocked at the base of the neck by the choke rope the vein becomes enlarged and rigid because of the back pressure. If the choke rope is sufficiently tight the vein stands out and can be easily seen and felt in thin-necked animals. As a further check in identifying the vein tap it with the fingers in front of the choke rope. Pulsations that can be seen or felt with the fingers in front of the point being tapped will confirm the fact that the vein is properly distended. It is impossible to put the needle into the vein unless it is distended. Experienced operators are able to raise the vein simply by hand pressure but the use of a choke rope is more certain.
- Inserting the needle. This involves three distinct steps. First insert the needle through the hide. Second insert the needle into the vein. This may require two or three attempts before the vein is entered. The vein has a tendency to roll away from the point of the needle especially if the needle is not sharp. The vein can be steadied with the thumb and finger of one hand. With the other hand the needle point is placed directly over the vein slanting it so that its direction is along the length of the vein either toward the head or toward the heart. Properly positioned this way a quick thrust of the needle will be followed by a spurt of blood through the needle which indicates that the vein has been entered. Third once in the vein the needle should be inserted along the length of the vein all the way to the hub exercising caution to see that the needle does not penetrate the opposite side of the vein. Continuous steady flow of blood through the needle indicates that the needle is still in the vein. If blood does not flow continuously the needle is out of the vein (or clogged) and another attempt must be made. If difficulty is encountered it may be advisable to use the vein on the other side of the neck.
- While the needle is being placed in proper position in the vein an assistant should get the medication ready so that the injection can be started without delay after the vein has been entered.
- Making the injection. With the needle in position as indicated by continuous flow of blood release the choke rope by a quick pull on the free end. This is essential--the medication cannot flow into the vein while it is blocked. Immediately connect the syringe containing Bio-Mycin 200 (oxytetracycline injection) to the needle and slowly depress the plunger. If there is resistance to depression of the plunger this indicates that the needle has slipped out of the vein (or is clogged) and the procedure will have to be repeated. Watch for any swelling under the skin near the needle which would indicate that the medication is not going into the vein. Should this occur it is best to try the vein on the opposite side of the neck.
- Removing the needle. When injection is complete remove needle with straight pull. Then apply pressure over area of injection momentarily to control any bleeding through needle puncture using cotton soaked in alcohol or other suitable antiseptic
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Description: Gilts normally reach puberty (begin experiencing normal estrous cycles and exhibiting regular estrus or heat) at any time between six and eight months of age although some gilts will not have exhibited their first estrus at ten months of age. Age at first estrus influenced by several factors including breed type season of the year environmental conditions and management practice (Hurtgen 1986).
Sows normally exhibit estrus three to seven days after weaning their litters; however some otherwise healthy sows may not exhibit estrus for 30 days or more after weaning (Dial and Britt 1986). The causes of delayed return to estrus in healthy sows are poorly understood but probably include season of the year (so-called seasonal anestrus; Hurtgen 1979) adverse environmental conditions such as high ambient temperatures (Love 1978) and the number of previous litters because the condition is more prevalent after the first litter than after later litters (Hurtgen 1986).
P.G. 600® is a combination of serum gonadotropin (Pregnant Mare Serum Gonadotropin or PMSG) and chorionic gonadotropin (Human Chorionic Gonadotropin or hCG) for use in prepuberal gilts (gilts that have not yet exhibited their first estrus) and in sows at weaning. It is supplied in freeze-dried form with sterile diluent for reconstitution.
The action of chorionic gonadotropin in gilts and sows is similar to the action of Luteinizing Hormone (LH) which is also produced by the animals’ anterior pituitary gland. It causes the release of mature ova from the follicles of the ovaries (ovulation) and it promotes the formation of corpora lutea which are necessary for the maintenance of pregnancy once the gilt has become pregnant.
The combination of serum gonadotropin and chorionic gonadotropin in P.G. 600 induces fertile estrus in most prepuberal gilts and weaned sows three to seven days after administration (Schilling and Cerne 1972; Britt et al. 1986; Bates et al. 1991). The animals may then be mated or in the case of gilts mating may be delayed until the second estrus after treatment.
Note: P.G. 600 is intended as a management tool to improve reproductive efficiency in swine production operations. To obtain maximum benefit from this product estrus detection and other aspects of reproductive management must be adequate. If you are in doubt about the adequacy of your breeding program consult your veterinarian.
Indications for Use: Prepuberal Gilts: P.G. 600 is indicated for induction of fertile estrus (heat) in healthy prepuberal (non-cycling) gilts over five and one-half months of age and weighing at least 85 kg (187 lb.).
Sows at weanng: P.G. 600 is indicated for induction of estrus in healthy weaned sows experiencing delayed return to estrus.
Cautions: Treatment will not induce estrus in gilts that have already reached puberty (begun to cycle). Gilts that are less than five and one-half months of age or that weight less than 85 kg (187 lb.) may not be mature enough to continue normal estrus cycles or maintain a normal pregnancy to full term after treatment.
Treatment will not induce estrus in sows that are returning to estrus normally three to seven days after weaning. Delayed return to estrus is most prevalent after the first litter; the effectiveness of P.G. 600 has not been established after later litters. Delayed return to estrus often occurs during periods of adverse environmental conditions and sows mated under such conditions may farrow smaller than normal litters.
Directions for Use:
Single Dose Vials: Using a sterile syringe and a sterile 0.90 x 38 mm (20 G x 1-1/2") hypodermic needle transfer the contents of one vial of sterile diluent (5 mL) into one vial of freeze-dried powder. Shake gently to dissolve the powder. Inject the contents of the vial into the gilt or sow’s neck behind the ear.
Storage Precautions: Store at or below room temperature 77°F (25°C).
Once reconstituted P.G. 600 should be used immediately. Unused solution should be disposed of properly and not stored for future use.
Spent hypodermic needles and syringes generated as a result of the use of this product must be disposed of properly in accordance with all applicable Federal State and local regulations.
